2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Drug Metabolite

Drug Metabolite

Drug Metabolite

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Drug metabolite results when a drug is metabolized into a modified form which continues to produce effects. Drug metabolism redox reactions such as heteroatom dealkylations, hydroxylations, heteroatom oxygenations, reductions, and dehydrogenations can yield active metabolites, and in rare cases even conjugation reactions can yield an active metabolite.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-118167
    Monoethylglycinexylidide
    Monoethylglycinexylidide is a metabolite of Lidocain (HY-B0185) via oxidative N-deethylation of Lignocaine by liver cytochrome P-450 enzymes in the liver[1].
    Monoethylglycinexylidide
  • HY-12771S
    O-Desmethyl Mebeverine acid-d5
    		98.45%
    O-Desmethyl Mebeverine acid-d5 is the deuterium labeled O-desmethyl Mebeverine acid.
    O-Desmethyl Mebeverine acid-d<sub>5</sub>
  • HY-143954S
    Epinephrine impurity 19-d3 hydrochloride
    Epinephrine impurity 19-d3 (hydrochloride) is the deuterium labeled Epinephrine impurity 19[1].
    Epinephrine impurity 19-d<sub>3</sub> hydrochloride
  • HY-150092
    8(S),9(R)-EET
    8(S),9(R)-EET is an eicosanoid product of Arachidonic acid (AA; HY-109590) by cytochromes P450. 8(S),9(R)-EET dilates canine epicardial arterioles in a concentration-dependent manner with an EC50 value of 121 nM.
    8(S),9(R)-EET
  • HY-135397
    (R)-​Linezolid
    (R)-Linezolid is an impurity of Linezolid (PNU-100766). Linezolid, the first member of the class of oxazolidinone synthetic antibiotic, acts by inhibiting the initiation of bacterial protein synthesis.
    (R)-​Linezolid
  • HY-B0199R
    Mycophenolate Mofetil (Standard)
    Mycophenolate Mofetil (Standard) is the analytical standard of Mycophenolate Mofetil. This product is intended for research and analytical applications. Mycophenolate mofetil (RS 61443) is the morpholinoethylester proagent of Mycophenolic acid. Mycophenolate mofetil inhibits de novo purine synthesis via the inhibition of inosine monophosphate dehydrogenase (IMPDH). Mycophenolate mofetil shows selective lymphocyte antiproliferative effects involve both T and B cells, preventing antibody formation.
    Mycophenolate Mofetil (Standard)
  • HY-126857S3
    5-Hydroxyomeprazole-d3-1
    5-Hydroxyomeprazole-d3-1 is the deuterium labeled 5-Hydroxyomeprazole[1].
    5-Hydroxyomeprazole-d<sub>3</sub>-1
  • HY-G0006R
    Omeprazole sulfide (Standard)
    Omeprazole sulfide (Standard) is the analytical standard of Omeprazole sulfide. This product is intended for research and analytical applications. Omeprazole metabolite Omeprazole sulfide (Ufiprazole) is a metabolite of Omeprazole.
    Omeprazole sulfide (Standard)
  • HY-135410
    ABZ-amine
    ABZ-amine (Amino albendazole) is an impurity of Albendazole. Albendazole is a member of the benzimidazole compounds used as a agent indicated for the treatment of a variety of worm infestations.
    ABZ-amine
  • HY-131274
    Fexofenadine Impurity F
    Fexofenadine Impurity F is the impurity of Fexofenadine. Fexofenadine, a H1R antagonist, is an anti-allergic agent used in seasonal allergic rhinitis and chronic idiopathic urticarial.
    Fexofenadine Impurity F
  • HY-143963S
    Irbesartan impurity 20-d4
    Irbesartan impurity 20-d4 is the deuterium labeled Irbesartan impurity 20[1]. Irbesartan impurity 20-d4 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Irbesartan impurity 20-d<sub>4</sub>
  • HY-143980S
    Losartan impurity 21-d4
    Losartan impurity 21-d4 is the deuterium labeled Losartan impurity 21[1]. Losartan impurity 21-d4 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Losartan impurity 21-d<sub>4</sub>
  • HY-12781S
    Desbutyl Lumefantrine-d9
    Desbutyl Lumefantrine-d9 is the deuterium labeled euterium labeled, which is a metabolite of Lumefantrine.
    Desbutyl Lumefantrine-d<sub>9</sub>
  • HY-135335
    3'-Hydroxy Repaglinide
    3'-Hydroxy Repaglinide is a main CYP2C8 metabolite of Repaglinide. Repaglinide is a carbamoylmethyl benzoic acid (CMBA) derivative, which recently has become available for the treatment of type II diabetes.
    3'-Hydroxy Repaglinide
  • HY-130569S1
    7-Hydroxymethotrexate-d3
    7-Hydroxymethotrexate-d3 is the deuterium labeled 7-Hydroxymethotrexate. 7-Hydroxymethotrexate is a major metabolite of Methotrexate (MTX; HY-14519). Methotrexate, an antimetabolite and antifolate agent, inhibits the enzyme dihydrofolate reductase, thereby preventing the conversion of folic acid into tetrahydrofolate, and inhibiting DNA synthesis[1][2].
    7-Hydroxymethotrexate-d<sub>3</sub>
  • HY-133694
    2-Aminoflubendazole
    2-Aminoflubendazole is the metabolite of Benzimidazoles. Benzimidazoles (BZ) are a class of agents with activities against fungi, protozoa, and helminthes.
    2-Aminoflubendazole
  • HY-135407S
    N-Desethyl Oxybutynin-d5 hydrochloride
    N-Desethyl Oxybutynin-d5 (hydrochloride) is deuterium labeled N-Desethyl Oxybutynin hydrochloride. N-Desethyl Oxybutynin is the the active metabolite Oxybutynin. Oxybutynin is an anticholinergic agent that inhibits voltage-dependent K+ channels[1].
    N-Desethyl Oxybutynin-d<sub>5</sub> hydrochloride
  • HY-W059917
    AP24600
    AP24600 is an inactive metabolite of Ponatinib.
    AP24600
  • HY-Z2106S
    Vonoprazan impurity 11-d5 fumarate
    Vonoprazan impurity 11-d5 (fumarate) is deuterium labeled 1-(5-(2-Fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrol-3-yl)-N-((5-(2-fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrol-3-yl)methyl)-N-methylmethanamine (Vonoprazan Impurity).
    Vonoprazan impurity 11-d<sub>5</sub> fumarate
  • HY-135374
    (3R,5S)-Atorvastatin sodium
    (3R,5S)-Atorvastatin sodium is an impurity of Atorvastatin. Atorvastatin is an orally active HMG-CoA reductase inhibitor, has the ability to effectively decrease blood lipids. Atorvastatin inhibits human SV-SMC proliferation and invasion with IC50s of 0.39 μM and 2.39 μM, respectively.
    (3R,5S)-Atorvastatin sodium
Cat. No. Product Name / Synonyms Application Reactivity